[Update and controversies of adjunctive sepsis therapy]

The implementation of the sepsis bundles have led to a remarkable reduction of mortality. The early treatment is one key factor, but there are differences in the effectiveness of single bundle measures to contribute to decreased mortality. The validation of newly introduced management or therapeutic interventions like tight glucose control in randomized controlled trials is not completely successful for patients suffering from severe sepsis or septic shock. Recently published guidelines attenuate implemented treatment strategies and lead to further adjustment taking into account actual data on adjunctive sepsis therapy.