Related Experiment Video
Updated: Jun 8, 2026
09:39
Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
[All together now: long term potentiation in the human cortex]
Daniel A Córdoba-Montoya1, Jacobo Albert, Sara López-Martín
1Biopsychology Laboratory, Department of Psychology, Fayetteville State University, Fayetteville, NC 28301, USA. dmontoya@uncfsu.edu
Revista De Neurologia
|September 15, 2010
Summary
Long-term potentiation (LTP), a key process for learning and memory, is being increasingly studied in the human cortex. Further research is needed to understand its mechanisms and potential as a cognitive enhancer.
Area of Science:
- Neuroscience
- Synaptic Plasticity
Context:
- Long-term potentiation (LTP) is a fundamental mechanism for learning and memory, extensively studied in animal models.
- Limited research has explored similar phenomena in the human cortex despite decades of investigation.
Purpose:
- To review the current understanding of LTP-like phenomena in the human cortex.
- To explore the applicability of known LTP mechanisms to human cortical function.
Summary:
- This review examines the evidence for LTP-like plasticity in the human brain.
- It discusses the potential for translating findings from animal models to humans.
- The review highlights the need for focused research in this area.
Impact:
- Understanding human cortical plasticity can advance cognitive enhancer development.
- Detailed knowledge of synaptic plasticity is crucial for designing new pharmacological agents.
- Further research will significantly impact neuroplasticity and cognitive function studies.
More Related Videos
Related Concept Videos
01:35Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
01:25Long-term Potentiation
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Hebbian LTP
LTP can occur when presynaptic neurons...
01:03Long-term Depression
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Calcium Ion Concentration Mechanism
If over time, all...
01:05Long-term Depression
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
01:14Action Potential
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...