Related Experiment Video

Updated: Jun 8, 2026

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
06:15

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

Psychological stress and coeliac disease in childhood: a cohort study

Karl Mårild1, Anneli Sepa Frostell, Jonas F Ludvigsson

  • 1Astrid Lindgren Children's Hospital, Karolinska University Hospital, Solna, Sweden. karlmarild@gmail.com

BMC Gastroenterology
|September 16, 2010
PubMed

Insights

This study found no link between family stress and childhood celiac disease (CD) in Swedish children. Limited statistical power may have influenced these findings, warranting further investigation into stress and CD development.

Area of Science:

  • Pediatric immunology
  • Gastroenterology
  • Psychoneuroimmunology

Background:

  • Psychological stress is linked to immunological diseases like inflammatory bowel disease.
  • The ABIS study (All Babies In southeast Sweden) investigated family stress and childhood celiac disease (CD).

Purpose of the Study:

  • To examine the association between psychological stress in the family and biopsy-proven celiac disease (CD) in children.
  • To determine if serious life events, parenting stress, or parental worries impact CD development.

Main Methods:

  • Utilized questionnaire data on serious life events, parenting stress, and parental worries.
  • Collected data from approximately 11,000 children at age 1 and 8,800 at age 2.5.
  • Validated celiac disease diagnoses through small intestinal biopsy (villous atrophy) and patient chart review.

Main Results:

  • No association was found between serious life events in the first 1-2.5 years and future CD diagnosis.
  • Parenting stress at ages 1 and 2.5 years showed no significant association with CD.
  • Parental worries at 2.5 years did not correlate with CD development, with an odds ratio of 0.00 (95% CI = 0.00-2.34).

Conclusions:

  • This study found no evidence of an association between psychological stress and the later development of celiac disease in Swedish children.
  • The absence of a statistically significant association may be attributed to insufficient statistical power, suggesting further research is needed.
Abstract

More Related Videos

The Trier Social Stress Test Protocol for Inducing Psychological Stress09:39

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Psychological Responses to Stress01:20

Psychological Responses to Stress

Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...