Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimal designs for discrete-time survival models with competing risks.

Lifetime data analysis·2026
Same author

Two-level non-regular fractional factorial designs for public health studies.

BMC medical research methodology·2026
Same author

Minimax optimal designs via particle swarm optimization methods.

Statistics and computing·2025
Same author

An Efficient Way to Find Optimal Crossover Designs Using CVX for Precision Medicine.

Journal of data science, statistics, and visualisation·2025
Same author

Nature-inspired metaheuristics for optimizing dose-finding and computationally challenging clinical trial designs.

Clinical trials (London, England)·2025
Same author

Design optimization of longitudinal studies using metaheuristics: Application to lithium pharmacokinetics.

Statistical methods in medical research·2025

Related Experiment Video

Updated: Jun 8, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Handling missing data issues in clinical trials for rheumatic diseases.

Weng Kee Wong1, W J Boscardin, A E Postlethwaite

  • 1Department of Biostatistics, School of Public Health, University of California at Los Angeles, CA 90095-1772, USA. wkwong@ucla.edu

Contemporary Clinical Trials
|September 16, 2010
PubMed
Summary
This summary is machine-generated.

Missing data in rheumatic disease clinical trials can alter treatment efficacy conclusions. Last observation carried forward is not recommended; explore advanced statistical methods for reliable results.

Related Experiment Videos

Last Updated: Jun 8, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

Area of Science:

  • Clinical Trials
  • Rheumatology
  • Biostatistics

Background:

  • Missing data are common in rheumatic disease clinical trials, necessitating robust statistical handling.
  • Inappropriate methods for managing missing data can lead to biased conclusions regarding treatment efficacy.

Purpose of the Study:

  • To review statistical techniques for analyzing longitudinal clinical trial data with missing values.
  • To highlight the impact of different missing data handling methods on treatment efficacy conclusions in rheumatic diseases.
  • To recommend against using "last observation carried forward" as a primary analysis method.

Main Methods:

  • Review of basic considerations and statistical techniques for missing data in longitudinal studies.
  • Application of various missing data handling methods to clinical trial data from diffuse systemic sclerosis patients.
  • Discussion of software, including a freely available library, for analyzing missing data, especially when dropout depends on unobserved values.

Main Results:

  • Different approaches to handling missing data yielded divergent conclusions on treatment efficacy in diffuse systemic sclerosis.
  • The "last observation carried forward" method can produce misleading results and should not be the primary analysis.

Conclusions:

  • Statistical methods for handling missing data significantly influence findings in rheumatic disease clinical trials.
  • Advanced statistical techniques are crucial for accurate analysis of longitudinal data with missingness.
  • The choice of missing data method must be carefully considered to ensure valid and reliable trial outcomes.