Related Experiment Video

Updated: Jun 8, 2026

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
09:20

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS

Published on: August 10, 2017

[Development of HDAC inhibitors]

Yoshihiro Sowa1

  • 1Dept. of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|September 16, 2010
PubMed

Insights

Epigenetic abnormalities play a key role in cancer development. Histone deacetylase (HDAC) inhibitors are a promising class of anti-tumor drugs with epigenetic effects, showing potential in clinical trials.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Context:

  • Carcinogenesis involves both genetic and epigenetic abnormalities.
  • Epigenetic modifications are increasingly recognized as crucial in cancer development.
  • Histone deacetylase (HDAC) inhibitors represent a class of compounds with demonstrated anti-tumor activity via epigenetic mechanisms.

Purpose:

  • To review the role of epigenetic abnormalities in carcinogenesis.
  • To highlight the therapeutic potential of histone deacetylase (HDAC) inhibitors.
  • To emphasize the need for biomarkers and combination strategies for HDAC inhibitors.

Summary:

  • Epigenetic abnormalities, alongside genetic mutations, are integral to cancer mechanisms.
  • Histone deacetylase (HDAC) inhibitors, such as vorinostat and romidepsin, exert anti-tumor effects through epigenetic modulation.
  • Several HDAC inhibitors are in clinical trials for monotherapy and combination treatments, building on FDA-approved drugs for cutaneous T-cell lymphoma.

Impact:

  • Establishes the significance of epigenetic factors in cancer.
  • Identifies HDAC inhibitors as a key therapeutic strategy.
  • Underscores the importance of personalized medicine approaches, including biomarker identification and optimized combination therapies, for maximizing the efficacy of HDAC inhibitors in cancer treatment.

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