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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

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Published on: October 14, 2016

Epidemiological data for common bone sarcomas.

Asim Qureshi1, Zubair Ahmad, Muhammad Azam

  • 1Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan. asimqureshi32@hotmail.com

Asian Pacific Journal of Cancer Prevention : APJCP
|September 17, 2010
PubMed
Summary
This summary is machine-generated.

Epidemiological data on bone sarcomas in Pakistan is scarce. This study found that while most bone sarcoma trends in Pakistan mirror Western data, chondrosarcoma (a type of bone cancer) is more common in younger patients.

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Area of Science:

  • Orthopedic Oncology
  • Cancer Epidemiology
  • Pathology

Background:

  • Limited epidemiological data exists for bone sarcomas in South Asia, particularly Pakistan.
  • Bone sarcomas, including osteosarcoma, Ewing's sarcoma, and chondrosarcoma, represent significant oncological challenges.

Purpose of the Study:

  • To compile epidemiological data on age, gender, and site distribution of common bone sarcomas in Pakistan.
  • To compare these findings with published Western data to identify population-specific differences.

Main Methods:

  • Retrospective analysis of osteosarcoma, Ewing's sarcoma, and chondrosarcoma cases at a major Pakistani histopathology center.
  • Data collection focused on patient demographics (age, gender) and tumor location.
  • Comparative analysis with existing international epidemiological studies.

Main Results:

  • Osteosarcomas predominantly affected individuals in their second and third decades, with a male predominance and common sites including the femur, tibia, and hip.
  • Ewing's Sarcomas were also more common in males, primarily occurring in the first three decades, with vertebrae, tibia, femur, and hip being frequent sites.
  • Chondrosarcomas exhibited a broad age distribution, with a notable prevalence in younger patients, and less frequent involvement of upper limb bones compared to Western data.

Conclusions:

  • Bone sarcoma epidemiology in Pakistan shares similarities with Western populations regarding osteosarcoma and Ewing's sarcoma demographics and common sites.
  • A key difference observed is the higher incidence of chondrosarcoma in younger individuals in the Pakistani cohort.
  • Further research is warranted to elucidate the specific etiological factors and optimize management strategies for bone sarcomas in this region.