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Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
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Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
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Inhalational Anesthetics: Overview01:20

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Guidelines for Elective Pediatric Fiberoptic Intubation
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Propofol infusion syndrome.

Jeremy M Wong1

  • 1Department of Anesthesiology, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, Los Angeles, CA 90095, USA. jeremywong@mednet.ucla.edu

American Journal of Therapeutics
|September 17, 2010
PubMed
Summary
This summary is machine-generated.

Propofol infusion syndrome (PRIS) is a rare but serious condition. This review covers its history, occurrence, symptoms, mechanisms, and treatments.

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Area of Science:

  • Anesthesiology
  • Critical Care Medicine
  • Pharmacology

Background:

  • Propofol is a widely used anesthetic agent.
  • Propofol infusion syndrome (PRIS) is a rare but potentially fatal complication associated with its prolonged administration.
  • Understanding PRIS is crucial for patient safety in intensive care settings.

Purpose of the Study:

  • To provide a comprehensive overview of propofol infusion syndrome.
  • To review the historical context, epidemiological data, clinical presentation, underlying pathophysiology, and current treatment strategies for PRIS.

Main Methods:

  • This study is a review of existing literature on propofol infusion syndrome.
  • Information was gathered from various sources including medical journals, case reports, and clinical guidelines.
  • The review synthesizes data on the history, incidence, presentation, pathophysiology, and treatment of PRIS.

Main Results:

  • Propofol infusion syndrome is characterized by metabolic acidosis, rhabdomyolysis, hyperkalemia, and cardiac dysfunction.
  • Risk factors include high doses, prolonged infusion, and critical illness.
  • Early recognition and intervention are key to improving outcomes.

Conclusions:

  • Propofol infusion syndrome requires vigilant monitoring in patients receiving long-term propofol infusions.
  • Further research is needed to elucidate the exact mechanisms and optimize treatment protocols.
  • Awareness and prompt management can mitigate the severity of PRIS.