Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reverse magnetic resonance signal from intraocular hemorrhage.

Retinal cases & brief reports·2014

Same author

Intravitreal bevacizumab (avastin) and ranibizumab (lucentis) for choroidal neovascularization overlying choroidal osteoma.

Retinal cases & brief reports·2014

Same author

Retinoblastoma in a 48-year-old woman.

Retinal cases & brief reports·2014

Same author

Neovascular glaucoma as the presenting sign of metastatic small cell lung carcinoma.

Retinal cases & brief reports·2014

Same author

Partial regression of vitreoretinal lymphoma after fine needle aspiration biopsy.

Retinal cases & brief reports·2014

Same author

Sclerochoroidal calcification in a patient with chronic hypercalcemia from undiagnosed parathyroid adenoma.

Retinal cases & brief reports·2014

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Small choroidal melanoma with monosomy 3.

Fariba Ghassemi¹, Carol L Shields, Miguel A Materin

¹Department of Ocular Oncology Service, Wills Eye Institute, Philadelphia, PA, USA.

Middle East African Journal of Ophthalmology

|September 17, 2010

Summary

This study details a small choroidal melanoma case in a patient with chromosome 3 monosomy. Treatment with I(125) plaque radiotherapy and transpupillary thermotherapy (TTT) led to tumor regression and vision improvement.

Keywords:

Choroidal Melanoma Chromosome 3 Eye Metastases Monosomy Small Choroidal Melanoma

More Related Videos

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Related Experiment Videos

Last Updated: Jun 8, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Area of Science:

Ophthalmology
Oncology

Background:

Choroidal melanomas are rare eye cancers.
Chromosome 3 monosomy is a known risk factor for metastasis in choroidal melanoma.

Purpose of the Study:

To describe a case of small juxtapapillary choroidal melanoma with chromosome 3 monosomy.
To report the outcomes of combined I(125) plaque radiotherapy and transpupillary thermotherapy (TTT) for this condition.

Main Methods:

A 64-year-old male with blurred vision was diagnosed with a small choroidal melanoma.
Tumor biopsy revealed chromosome 3 monosomy.
Treatment involved I(125) plaque radiotherapy and one session of TTT.

Main Results:

At one year post-treatment, the choroidal melanoma showed regression.
Subretinal fluid resolved, and visual acuity improved to 20/40.
The case highlights the presence of chromosome 3 monosomy in small choroidal melanomas.

Conclusions:

Small choroidal melanomas can exhibit chromosome 3 monosomy.
Combined I(125) radiotherapy and TTT can be an effective treatment for selected cases.
Chromosome 3 monosomy in choroidal melanoma warrants careful monitoring for systemic metastasis.