Related Experiment Video
Updated: Apr 21, 2026
Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Regression of advanced group e retinoblastoma with intraarterial chemotherapy
Aparna Ramasubramanian1, Neelema Sinha, Robert H Rosenwasser
1*Ocular Oncology Service, Wills Eye Institute, Philadelphia, Pennsylvania †Department, of Cerebrovascular Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
Purpose:
To report a case of regression of advanced retinoblastoma with intraarterial chemotherapy.
Methods:
A 25-month-old boy presented with extensive endophytic group E retinoblastoma with extensive vitreous seeds and total retinal detachment.
Results:
The patient underwent four sessions of intraarterial chemotherapy after which there was complete regression of vitreous seeds and near-complete calcification of the tumor.
Conclusion:
Intraarterial chemotherapy is a novel treatment that is effective in selected cases of retinoblastoma. This technique allows selective delivery of chemotherapy to the involved tumor tissue with minimal systemic absorption.
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