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Published on: September 8, 2023
Genome scan for locus involved in mandibular prognathism in pedigrees from China
1Department of Orthodontics, Dental School, Tongji University, Shanghai, China.
Background:
It is well known that genetic components play an important role in the etiology of mandibular prognathism, but few susceptibility loci have been mapped.
Methodology:
In order to identify linkage regions for mandibular prognathism, we analyzed two Chinese pedigrees with 6,090 genome-wide single-nucleotide polymorphism (SNP) markers from Illumina Linkage-12 DNA Analysis Kit (average spacing 0.58 cM). Multipoint parametric and non-parametric (model-free) linkage analyses were used for the pedigrees.
Principal Finding:
The most statistically significant linkage results were with markers on chromosome 4 (LOD=3.166 and NPL=3.65 with rs 875864, 4p16.1, 8.38 cM). Candidate genes within the 4p16.1 include EVC, EVC2.
Conclusion:
We detected a novel suggestive linkage locus for mandibular prognathism in two Chinese pedigrees, and this linkage region provides target for susceptibility gene identification, a process that will provide important insights into the molecular and cellular basis of mandibular prognathism.
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