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Effects of renal dysfunction on cardiovascular events in diabetic patients with hypertension: challenge-DM Study

Satoshi Umemura1, Ryuzo Kawamori, Hiroaki Matsuoka

  • 1Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. umemuras@med.yokohama-cu.ac.jp

Clinical and Experimental Nephrology
|September 17, 2010
PubMed

Insights

Low estimated glomerular filtration rate (eGFR) is a risk factor for cardiovascular events in younger Japanese diabetic patients with hypertension. This risk was not observed in older patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Investigated the link between renal dysfunction and cardiovascular events in Japanese diabetic patients with hypertension on candesartan therapy.
  • Utilized data from the large-scale Challenge-DM Study.

Purpose of the Study:

  • To determine if low estimated glomerular filtration rate (eGFR) is an independent risk factor for cardiovascular events.
  • To analyze this relationship across different age groups.

Main Methods:

  • Assessed renal function (eGFR) in 4706 patients from the Challenge-DM Study.
  • Defined renal dysfunction as eGFR <60 ml/min/1.73 m(2).
  • Employed univariate and multivariate Cox regression analyses, considering patient characteristics and treatment targets.

Main Results:

  • Patients with low eGFR were older, more likely female, and had a higher prevalence of cardiovascular disease (CVD).
  • Low eGFR was associated with increased cardiovascular events in univariate analysis.
  • Multivariate analysis indicated low eGFR significantly influenced events in patients <65 years old, but not in those ≥65 years old.

Conclusions:

  • Low estimated glomerular filtration rate (eGFR) may be an independent risk factor for cerebrovascular and cardiovascular events.
  • This association is significant in younger and middle-aged Japanese diabetic patients with hypertension on candesartan therapy.
Abstract

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