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Cortical microvessels during brain development: a morphometric study in the rat.

R F Keep1, H C Jones

  • 1Biomedical Sciences Division, King's College London, United Kingdom.

Microvascular Research
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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Structural changes in the rat blood-brain barrier during development involve increased vascularity and altered mitochondrial volume. These changes, particularly after birth, correlate with evolving brain function and oxidative activity.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • The blood-brain barrier (BBB) undergoes functional and structural maturation during development.
  • Understanding these developmental changes is crucial for comprehending brain function and potential therapeutic interventions.

Purpose of the Study:

  • To investigate structural alterations in the rat blood-brain barrier during development.
  • To correlate these structural changes with developmental shifts in barrier function and brain oxidative activity.

Main Methods:

  • Morphometric analysis of rat visual cortex from 16 days gestation to adulthood.
  • Utilized light and electron microscopy to assess capillary structure, endothelial cell morphology, and mitochondrial volume.

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Main Results:

  • Capillary volume, number, and surface density increased in two phases: prenatal and postnatal (10-20 days).
  • Brain parenchymal mitochondria (oxidative activity marker) increased postnatally from 1.7% to 5.7%.
  • Endothelial cell thickness decreased, while total endothelial mitochondrial volume per tissue volume increased.

Conclusions:

  • BBB structural development involves distinct phases of vascular growth and mitochondrial adaptation.
  • Postnatal development significantly impacts BBB vascularity and mitochondrial content, influencing brain oxidative capacity.
  • Changes in endothelial cell thickness and mitochondrial dynamics contribute to the evolving BBB structure and function.