Related Experiment Video
Updated: Jun 8, 2026

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
[Clinical diagnostics and therapy for non-arteritic central retinal artery occlusion]
1Universitäts-Augenklinik, Freiburg. amelie.pielen@uniklinikfreiburg.de
Insights
Central retinal artery occlusion (CRAO) is an emergency requiring prompt diagnosis and treatment. This review guides interdisciplinary diagnostics and recommends multimodal therapy for non-arteritic CRAO.
Area of Science:
- Ophthalmology
- Vascular Medicine
- Neurology
Context:
- Central retinal artery occlusion (CRAO) is a critical ophthalmological emergency.
- Risk factors include hypertension, arrhythmias, atherosclerosis, hypercholesterolemia, and diabetes.
- Arteritic causes should be investigated in elderly patients, while thrombophilia is considered in younger individuals.
Purpose:
- To review the causes and diagnostic methods for CRAO.
- To critically evaluate existing therapeutic options for non-arteritic CRAO.
- To provide a guide for interdisciplinary diagnostics and recommend multimodal treatment strategies.
Summary:
- This review details the etiology and diagnostic approaches for CRAO.
- It critically assesses various interventions, including eye massage, IOP reduction, anticoagulation, and thrombolysis.
- A multimodal therapeutic approach, integrated with internal medicine and neurology, is proposed for non-arteritic CRAO.
Impact:
- Aims to standardize the diagnostic and therapeutic pathway for CRAO.
- Facilitates collaboration between ophthalmology, internal medicine, and neurology.
- Offers a structured approach to managing this sight-threatening condition.
Abstract:
Central retinal artery occlusion (CRAO) is an ophthalmological emergency situation. Known risk factors are arterial hypertension, cardial arrhythmia, arteriosclerosis, hypercholesterolemia and diabetes. Elderly patients should be examined for an arteritic genesis. Young patients (< 45 years) without typical risk factors may suffer from thrombophilia. There is no uniform recommendation on how to treat non-arteritic CRAO. Many different interventions have been suggested in the literature, i. e., massaging the eye, systemic or local reduction of intraocular pressure, anticoagulation, either systemically administered venous thrombolysis or supraselective intra-arterial thrombolysis. In this review we present the causes of CRAO and diagnostic means to detect causes; we also critically discuss previously described therapeutic options. It is our aim to provide a guide through the necessary interdisciplinary diagnostics in co-operation with internal medicine and neurology and to recommend a multimodal therapy in patients with non-arteritic CRAO.
Related Concept Videos
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Angle Closure Glaucoma: Treatment
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Diabetic Retinopathy