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B-cell lymphofollicular infiltrates in mycosis fungoides

Gerardo Ferrara¹, Concetta Chiarelli, Stefano Simonetti

¹Pathologic Anatomy Unit, Gaetano Rummo General Hospital, Benevento, Italy. gerardo.ferrara@libero.it

|September 18, 2010

Abstract

Aims And Background:

The histopathological picture of mycosis fungoides can be characterized by heavy reactive infiltrates. These are rarely composed of B lymphocytes with formation of reactive follicles.

Methods And Study Design:

We collected three cases of mycosis fungoides with a reactive B-cell lymphofollicular reaction at the bottom of the epidermotropic infiltrate.

Results:

Case 1 showed flat lesions (patches) with a CD4+ neoplastic phenotype; case 2 presented infiltrated lesions (plaques) with a CD8+ immonophenotype; case 3 was characterized by nodular lesions (tumors) with a CD4+ neoplastic component. In all three cases, no clonal gene rearrangement was found with the polymerase chain reaction technique.

Conclusions:

Among the protean clinicopathological features which mycosis fungoides can show, we underline that a B-cell lymphofollicular component can be encountered at the base of the epidermotropic infiltrate even in clinically flat ("patchy") lesions.

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