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Updated: Jun 8, 2026
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Study on DNA-binding and DNA-cleavage properties of Cr(III) complexes with polypyridyl ligands
Xi-Ling Liang1, Li-Feng Tan, Wei-Guo Zhu
1Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, PR China.
Abstract:
Two new water-soluble Cr(III) complexes [Cr(IP)(2)Cl(2)](+) and [Cr(PIP)(2)Cl(2)](+) (IP = imidazo[4,5-f][1,10]phenanthroline, PIP = 2-phenylimidazo[4,5-f][1,10]phenanthroline) were synthesized and characterized by elemental analysis, mass spectra, and ultraviolet-visible spectra. The DNA-binding properties of the two complexes were investigated by spectroscopic methods and viscosity measurements. The results indicate that both complexes bind to DNA via an intercalative mode with moderate strength. The fluorescence intensity of both complexes decreases with increasing DNA concentration, similar to those of [Cr(phen)(3)](3+) and [Cr(bpy)(3)](3+). Also, both complexes can cleave pBR-322 DNA in the presence of H(2)O(2), and [Cr(PIP)(2)Cl(2)](+) exhibits more effective activity than [Cr(IP)(2)Cl(2)](+) under the same condition.
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