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Microalbuminuria is not a valuable marker for relapse in Crohn's disease

C S Horjus1, M G H van Oijen, A H Davids

  • 1Department of Gastroenterology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

Digestion
|September 18, 2010
PubMed

Insights

Microalbuminuria was moderately common in patients with quiescent Crohn's disease (CD). However, this study found no significant association between microalbuminuria and disease activity or predicting relapses in CD patients.

Area of Science:

  • Gastroenterology
  • Nephrology
  • Clinical Medicine

Background:

  • Previous studies suggested a link between microalbuminuria and disease activity in Crohn's disease (CD).
  • The current research aimed to evaluate microalbuminuria's potential as a relapse marker in quiescent CD.

Purpose of the Study:

  • To determine if microalbuminuria predicts relapses in patients with quiescent Crohn's disease.
  • To assess the association between microalbuminuria and disease characteristics in CD.

Main Methods:

  • A 1-year prospective trial involving 139 patients with quiescent CD on oral budesonide.
  • Microalbuminuria was measured at baseline and throughout the follow-up period, including at relapse.
  • Statistical analysis included logistic regression and time-dependent Cox regression.

Main Results:

  • Microalbuminuria was present in 8 patients at randomization and in 11% of those who relapsed.
  • No statistically significant association was found between microalbuminuria and relapse (OR 0.92, 95% CI 0.76-1.13).
  • Time-dependent Cox regression also showed no predictive value for microalbuminuria (HR 1.29, 95% CI 0.37-4.39).

Conclusions:

  • Microalbuminuria showed moderate prevalence in quiescent CD patients.
  • It was not associated with disease characteristics or pre-randomization medication.
  • Microalbuminuria did not prove to be a reliable predictor of relapses in this cohort.
Abstract

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