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Updated: Jun 8, 2026
Surgical Treatment of an Endolymphatic Sac Tumor
Published on: May 26, 2023
Long-term results of 28 esthesioneuroblastomas managed over 35 years
Ludovic de Gabory1, Habib Merza Abdulkhaleq, Vincent Darrouzet
1Department of Otorhinolaryngology, Skull Base Surgery, Pellegrin University Hospital, Centre F-X Michelet, place A. Raba-Léon F-33076, Bordeaux Cedex, France. ludovic.de-gabory@chu-bordeaux.fr
Background:
The purpose of our study was to assess the long-term results in the management of patients with esthesioneuroblastoma.
Methods:
A total of 28 patients were retrospectively reviewed to analyze their clinical features, treatment outcomes, pattern of failures, and course of the disease.
Results:
The patients were classified as 2 patients with T1, 10 patients with T2, 10 patients with T3, and 6 patients with T4; the results of all were included in this study. Twenty-six patients underwent surgery and 23 had postoperative radiotherapy over the tumor bed, only 9 had radiotherapy over the nodes. The average follow-up was 99.11 months. Fifteen-year and 20-year disease-specific and disease-free survival rates were 88.6% to 66.4% and 59.6% to 29.8%, respectively. Six patients had recurrences and 60% of them occurred more than 10 years after treatment. In the first decade, nodal recurrences appeared earlier than local ones when patients with N0 did not undergo neck irradiation.
Conclusion:
Surgery on patients with T presentations and adjuvant radiotherapy on T and N0 neck presentations seem to be essential to treat esthesioneuroblastoma. A follow-up for a minimum of 20 years is necessary to ensure complete cure.
