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Updated: Jun 8, 2026

Cortisol Measurement in Koala (Phascolarctos cinereus) Fur
Published on: August 23, 2019
[Decreased expression of serum cortisol in patients with severe hepatitis]
Ling Gao1, Kai Wang, Jie-Fei Wang
1Department of Hepatology, Qilu Hospital of Shandong University, Hepatology Institute of Shandong University, Ji' nan 250012, China.
Objective:
To investigate the profile of serum cortisol levels in patients with severe hepatitis.
Methods:
Fifty patients with viral hepatitis (including 30 severe hepatitis patients and 20 chronic hepatitis B patients) were enrolled in this present study. Serum cortisol concentration was tested using radioimmunoassay. Furthermore, liver function, coagulation and other related laboratory indices were also determined.
Results:
Serum cortisol concentration of severe hepatitis group was lower than that of chronic hepatitis B group (P < 0.05) and lower than that of healthy controls (P < 0.05) serum cortisol concentration of severe hepatitis patients was significantly positively correlated with PTA (r = 0.445, P < 0.05); serum cortisol concentration has no relation with ALT in patients with severe hepatitis (P > 0.05), and serum cortisol concentration was significantly negatively correlated with the ratio of AST/ALT in patients with severe hepatitis (r = -0.367, P < 0.05). No significant relationship was found between serum cortisol concentration and total Bilirubin (P > 0.05). Serum cortisol concentration in death group of severe hepatitis was lower than that in survival group of severe hepatitis (P < 0.05). Of severe hepatitis patients with MELD score, the higher MELD score, the lower the cortisol concentration.
Conclusion:
Cortisol concentration decreased in patients with severe hepatitis, which was related to functional liver reserve and disease severity. Cortisol can be related to the prognosis of severe hepatitis patients.
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