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Updated: Jun 8, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
[Direct cytopathic effects of particular hepatitis B virus genotypes in immunosuppressive condition]
Yasuhito Tanaka1, Masaya Sugiyama, Masashi Mizokami
1Department of Virology & Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. ytanaka@med.nagoya-cu.ac.jp
Abstract:
Little is known about the direct cytopathic effect of hepatitis B virus (HBV) and its association with particular viral genotype or genetic mutation. In some immunosuppressed chronic HBV patients who had liver transplantation or HIV-coinfection, high viremia and liver fibrosis may occur. These findings suggest that hepatic injuries could arise in the absence of a mature immune system and the difference of genotype and/or specific mutation would affect cytopathic potential of the virus. We investigate HBV genotype-related differences in viral replication, antigens expression and histopathology using in vitro replication model or uPA/SCID mice harboring human hepatocytes, demonstrating that different HBV genotypes and even particular mutation are associated with different virological and histopathological characteristics. Infection with HBV/C2 as well as PC mutant of the HBV/B1 in immunosuppressive conditions can induce direct cytopathic effect in "humanized" part of the murine liver.
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