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Clinical Imaging of Microwave Mammography
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Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence.

Paul R Stauffer1, Paolo Maccarini, Kavitha Arunachalam

  • 1Radiation Oncology Department, Duke University, Durham, NC 27710, USA. paul.stauffer@duke.edu

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
|September 21, 2010
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Conformal microwave array applicators effectively heat large chest wall areas for cancer treatment. This technology offers superior coverage and patient tolerance compared to conventional hyperthermia devices.

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Area of Science:

  • Medical physics
  • Oncology
  • Biomedical engineering

Background:

  • Chest wall recurrence is a significant challenge in cancer treatment.
  • Conventional hyperthermia devices have limitations in treating large, contoured areas.
  • Microwave array applicators offer a potential solution for advanced thermal therapy.

Purpose of the Study:

  • To review current thermotherapy devices for chest wall recurrence.
  • To evaluate the largest conformal microwave array (CMA) applicator for its effectiveness in heating large areas.
  • To assess CMA applicators as an adjuvant to radiation, chemotherapy, and brachytherapy.

Main Methods:

  • Review of existing thermotherapy devices.
  • Evaluation of CMA applicator conformity using CT and MR scans.
  • Electromagnetic and thermal simulations for specific absorption rate (SAR) and temperature distribution.
  • In-situ SAR measurements.
  • Clinical pilot study assessing heating patterns and patient tolerance in 13 patients.

Main Results:

  • CMA applicators demonstrated excellent conformity to torso anatomy.
  • Simulations showed effective heating control over contoured areas.
  • Measurements confirmed gap-free coverage of large treatment areas (up to 500 cm²).
  • Treatments were well-tolerated, achieving target temperatures (Tmin=41.4°C, T90=42.1°C, Tave=42.8°C, Tmax=44.3°C).

Conclusions:

  • CMA applicators are effective for thermal therapy of large, superficial chest wall diseases.
  • This technology significantly expands treatment area coverage compared to conventional devices.
  • CMA applicators show promise for improving outcomes in adjuvant cancer therapy.