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Updated: Jun 8, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Recurrent erythema multiforme triggered by progesterone sensitivity.

Teresa J Nasabzadeh¹, Catherine M Stefanato, John E Doole

¹Washington Hospital Center, Department of Internal Medicine-Dermatology, 110 Irving Street NW, Washington DC 20010, USA. Teresa.J.Nasabzadeh@medstar.net

Journal of Cutaneous Pathology

|September 21, 2010

Summary

Recurrent erythema multiforme (EM) can be triggered by hormonal changes. This case highlights autoimmune progesterone dermatitis (APD) as a potential cause in women with cyclical EM flares.

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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Published on: October 12, 2012

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Published on: August 4, 2021

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

Dermatology
Immunology
Endocrinology

Background:

Recurrent erythema multiforme (EM) etiology is often unclear, with herpes simplex virus (HSV) implicated in some cases.
Identifying specific triggers for recurrent EM is crucial for effective patient management.

Observation:

A case of recurrent blistering eruption clinically and histopathologically consistent with EM was observed.
The patient's EM consistently flared during the luteal phase of her menstrual cycle.

Findings:

Investigation ruled out HSV as the causative factor for the patient's recurrent EM.
The findings suggest a hormonal influence, specifically autoimmune progesterone dermatitis (APD), as the etiology.
Elevated progesterone levels during the luteal phase are hypothesized to trigger the EM flares.

Implications:

This case underscores the importance of considering hormonal triggers, particularly APD, in women presenting with recurrent EM.
Recognizing cyclical patterns related to the menstrual cycle can aid in diagnosing APD.
Further research into hormonal influences on EM pathogenesis is warranted.