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Perianal mammary-type myofibroblastoma
Yaxia Zhang1, Merce Jorda, John R Goldblum
1Department of Pathology, University of Miami Miller School of Medicine/JMH, FL 33136, USA.
Annals of Diagnostic Pathology
|September 21, 2010
Summary
This study details a rare extramammary myofibroblastoma in the perianal region. This benign tumor, typically found in the breast, highlights the importance of considering diverse tumor origins.
Area of Science:
- Oncology
- Surgical Pathology
- Dermatopathology
Background:
- Extramammary myofibroblastomas are rare benign tumors, typically occurring in soft tissues.
- Mammary-type myofibroblastomas share histological features with their mammary gland counterparts.
- Perianal region masses require careful differential diagnosis, including rare mesenchymal neoplasms.
Observation:
- A case of extramammary myofibroblastoma in the perianal region of a 40-year-old female is presented.
- The tumor was a well-circumscribed, 5 cm nodular mass with a solid, yellow homogenous cut surface.
- Microscopic examination revealed bland spindled cells in fascicles with myxoid stroma.
Findings:
- Immunohistochemical staining showed strong positivity for desmin and CD34.
- This represents the eleventh reported case of extramammary, mammary-type myofibroblastoma in the literature.
- The histological and immunohistochemical profile supports the diagnosis of mammary-type myofibroblastoma.
Implications:
- This case expands the known anatomical distribution of extramammary myofibroblastomas.
- Accurate diagnosis is crucial for appropriate management and to exclude malignant differentials.
- Further research into the pathogenesis and behavior of extramammary myofibroblastomas is warranted.
