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Discrepancy among acute guideline levels for emergency response
Mattias Öberg1, Nicole Palmen1, Gunnar Johanson1
1Karolinska Institute, Institute of Environmental Medicine, Unit of Work Environment Toxicology, Stockholm, Sweden.
Journal of Hazardous Materials
|September 21, 2010
Summary
Acute Exposure Guidance Levels (AEGL) and Emergency Response Planning Guideline (ERPG) are similar in general caution for hazardous chemical releases. However, significant value differences for many substances may hinder risk communication and management.
Area of Science:
- Public Health
- Environmental Science
- Toxicology
Background:
- Acute guidance values are crucial for public health risk assessment during hazardous chemical releases.
- The Acute Exposure Guidance Levels (AEGL) and Emergency Response Planning Guideline (ERPG) are widely used systems.
Purpose of the Study:
- To compare AEGL and ERPG values qualitatively and quantitatively.
- To identify reasons for divergence in guidance values.
- To suggest factors for international harmonization of values.
Main Methods:
- Qualitative and quantitative comparison of AEGL and ERPG values.
- Analysis of discrepancies based on critical effect, critical study selection, and interpretation.
- Review of factors influencing international acceptance of harmonized values.
Main Results:
- AEGL and ERPG values show no significant general difference in caution.
- Guidance values diverge by a factor of 3 or more for nearly 40% of substances.
- Discrepancies arise from differences in critical effect/study selection and interpretation.
Conclusions:
- While generally similar, diverging AEGL and ERPG values can impede effective risk communication and management.
- Transparency, standardized toxicological tiers, and inclusion of sensitive populations are key for harmonized values.
- Development of purely health-based values and separate treatment of risk management issues are recommended.
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