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Related Experiment Video

Updated: Jun 8, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Microbubble-enhanced US in body imaging: what role?

Stephanie R Wilson¹, Peter N Burns

¹Department of Diagnostic Imaging, Foothills Medical Centre, University of Calgary, Calgary, AB, Canada. stephanie.wilson@albertahealthservices.ca

|September 21, 2010

Summary

Contrast-enhanced ultrasound (CE US) utilizes microbubble contrast agents for detailed imaging. CE US offers accurate, noninvasive diagnosis and monitoring for various conditions, improving patient care without radiation or nephrotoxicity.

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Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

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Published on: June 12, 2021

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Published on: April 9, 2021

Area of Science:

Medical imaging
Diagnostic ultrasound
Contrast-enhanced ultrasonography

Background:

Contrast agents for ultrasonography (US) are gas-filled microbubbles with encapsulating shells.
These agents interact with ultrasound fields, oscillating at low intensity and disrupting at high intensity.
New contrast-specific imaging modes enhance US visualization of vascularity and tissue perfusion.

Purpose of the Study:

To review the established and emerging applications of contrast-enhanced ultrasound (CE US).
To highlight the diagnostic accuracy and clinical utility of CE US in various medical fields.
To emphasize the safety and practical advantages of microbubble contrast agents.

Main Methods:

Utilizes contrast-specific imaging modes with microbubble contrast agents.
Employs ultrasound fields to elicit responses from microbubble contrast agents.
Compares diagnostic accuracy with computed tomography and magnetic resonance imaging.

Main Results:

CE US enables noninvasive diagnosis of focal liver masses with accuracy comparable to CT and MRI.
It is a preferred modality for diagnosing liver nodules in patients at risk for hepatocellular carcinoma.
Emerging applications include guiding interventions, monitoring inflammatory bowel disease, characterizing kidney and prostate masses, and assessing tumor response to therapy.

Conclusions:

Microbubble contrast agents are easy to use, robust, and pose no risk of nephrotoxicity or ionizing radiation.
CE US plays a vital and expanding role in improving patient management and care.
CE US offers excellent real-time imaging with high spatial resolution for vascularity and perfusion.