Midterm experience with implantable cardioverter-defibrillators in children and young adults

Alpay Çeliker1, Haşim Olgun, Tevfik Karagoz

  • 1Department of Pediatric Cardiology, Acıbadem University, Maslak Hospital, İstanbul, Turkey.

Insights

Implantable cardioverter-defibrillators (ICDs) are safe for children at high risk of sudden cardiac death, but lead complications and frequent shocks, often due to T-wave oversensing, impact quality of life.

Area of Science:

  • Pediatric Cardiology
  • Electrophysiology
  • Medical Device Technology

Background:

  • Implantable cardioverter-defibrillators (ICDs) are crucial for managing life-threatening arrhythmias in pediatric patients.
  • Experience with ICD implantation in children with diverse etiologies is valuable for refining treatment strategies.

Purpose of the Study:

  • To review the single-center experience with implantable cardioverter-defibrillator (ICD) implantation in pediatric patients.
  • To evaluate the safety, efficacy, and complications associated with ICDs in children with various underlying conditions.

Main Methods:

  • Retrospective review of pediatric patients who underwent ICD implantation between October 2001 and December 2008.
  • Data collection from medical records and computerized databases.
  • Analysis of patient demographics, diagnoses, device types, shock data, and complications.

Main Results:

  • Twenty-eight pediatric patients (median age 12 years) received ICDs for secondary (n=22) or primary (n=6) prevention.
  • Ion-channel diseases and cardiomyopathy were the most common etiologies.
  • Appropriate shocks occurred in 68.2% of secondary and 33.3% of primary prevention groups.
  • Inappropriate shocks (n=42) occurred in 31.8% of patients, primarily due to T-wave oversensing.
  • Lead complications occurred in six patients.

Conclusions:

  • ICDs are safe and effective in interrupting malignant arrhythmias in high-risk pediatric patients.
  • Lead complications and a high incidence of both appropriate and inappropriate shocks necessitate careful device programming.
  • T-wave oversensing is a significant issue contributing to inappropriate shocks, requiring optimized programming to improve patient quality of life.
Abstract

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiopulmonary Resuscitation I: Adult01:21

Cardiopulmonary Resuscitation I: Adult

Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...