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Updated: Jun 8, 2026

Evaluation of the Efficacy of the H. pylori Protein HP-NAP as a Therapeutic Tool for Treatment of Bladder Cancer in an Orthotopic Murine Model
Published on: May 29, 2015
Granulomatous hepatitis after intravesical bacillus Calmette-Guérin treatment
Maddalena Adami1, Igor Marsteller, Luca Mazzucchelli
1Dipartimento di Medicina Interna, Ospedale Regionale di Lugano, Lugano, Switzerland.
Abstract:
A 79-y-old man presented with systemic inflammatory response syndrome (SIRS) and jaundice, 6 h after the first intravesical instillation of bacillus Calmette-Guérin (BCG) for bladder cancer; he had a subsequent reaction 4 weeks later. Liver biopsy findings were compatible with BCG hepatitis. Anti-mycobacterial treatment induced complete recovery. The first episode probably represents a hypersensitivity reaction, whereas the latter course suggests BCG dissemination.
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