Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
Local Anesthetics: Chemistry and Structure-Activity Relationship01:30

Local Anesthetics: Chemistry and Structure-Activity Relationship

Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum lactate dehydrogenase is associated with the presence and extent of preoperative peritumoral edema in melanoma brain metastases.

Journal of neuro-oncology·2026
Same author

Diagnostic Accuracy of Ex Vivo Confocal Laser Scanning Microscopy for Routine Detection of Cutaneous Squamous Cell Carcinoma and Actinic Keratoses.

Cancers·2026
Same author

Disc-Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Atopic Multimorbidity in Adults With a Focus on Sensitization Patterns and T Cell Activation.

Clinical and translational allergy·2025
Same author

[Painful, cicatricial inflammation of the penile shaft-paraffinoma].

Dermatologie (Heidelberg, Germany)·2025
Same author

[Trichophyton mentagrophytes ITS genotype VIII/Trichophyton indotineae in Germany-revisit after 5 years].

Dermatologie (Heidelberg, Germany)·2025
Same journal

The different face of skin-rash induced by brentuximab vedotin.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Repositioning Non-Ablative Fractional Lasers - Molecular and Histological Insights from a scoping review.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Infusion-site reactions to foslevodopa/foscarbidopa in Parkinson's disease.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Tranexamic Acid-Soaked Intranasal Packing for Postoperative Bleeding After Nasal Interpolation Flap Repair.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Monoclonal gammopathy of dermatological significance: non-amyloid paraprotein deposits with light and heavy chains.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Papular epidermal nevus with "skyline" basal cell layer: Clinical clues from a three-member family.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
See all related articles

Related Experiment Video

Updated: Jun 8, 2026

CO2-Lasertonsillotomy Under Local Anesthesia in Adults
05:07

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

Published on: November 6, 2019

Local anesthesia in dermatology.

Tino Wetzig1, Marco Averbeck, Jan C Simon

  • 1Department of Dermatology, Venereology and Allergy, University of Leipzig, Germany. wett@medizin.uni-leipzig.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|September 22, 2010
PubMed
Summary
This summary is machine-generated.

Local and regional anesthesia are essential in dermatology for pain management during procedures. Tumescent local anesthesia offers a safe alternative to general anesthesia, especially for elderly patients with co-morbidities, reducing surgical risks.

More Related Videos

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
04:12

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Published on: January 19, 2024

Related Experiment Videos

Last Updated: Jun 8, 2026

CO2-Lasertonsillotomy Under Local Anesthesia in Adults
05:07

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

Published on: November 6, 2019

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
08:01

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
04:12

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Published on: January 19, 2024

Area of Science:

  • Dermatology
  • Anesthesiology

Background:

  • Local and regional anesthetic procedures are fundamental in dermatological practice.
  • Effective analgesia is critical for patient comfort during skin and soft tissue interventions.
  • Older patients with comorbidities may benefit from local anesthetic procedures to minimize surgical risks.

Purpose of the Study:

  • To highlight the importance of local and regional anesthesia in dermatology.
  • To emphasize the benefits of tumescent local anesthesia for pain-free interventions.
  • To underscore the necessity of understanding local anesthetic properties and complication management for dermatologists.

Main Methods:

  • Review of the role and application of local and regional anesthesia in dermatological procedures.
  • Discussion of tumescent local anesthesia as a technique for minimally invasive interventions.
  • Emphasis on the safety profile and risk reduction in specific patient populations.

Main Results:

  • Tumescent local anesthesia enables pain-free procedures, potentially avoiding general anesthesia.
  • Local anesthetic procedures can significantly decrease surgical risks, particularly in elderly patients with multiple health issues.
  • Knowledge of local anesthetic mechanisms, toxicity, and emergency management is vital for dermatologists.

Conclusions:

  • Local and regional anesthesia are indispensable tools in dermatological practice.
  • Tumescent local anesthesia provides a safe and effective analgesic option, broadening the scope of office-based procedures.
  • Dermatologists must possess comprehensive knowledge of local anesthetics to ensure patient safety and optimal outcomes.