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Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

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Published on: March 30, 2017

Air permeability of powder: a potential tool for Dry Powder Inhaler formulation development.

V N P Le¹, E Robins, M P Flament

¹College of Pharmacy, Université Lille Nord de France, Lille, France.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V

|September 22, 2010

Summary

This summary is machine-generated.

Measuring powder bed air permeability offers a new way to predict Dry Powder Inhaler performance. This simple method helps screen formulations for better drug delivery.

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Area of Science:

Pharmaceutical Sciences
Materials Science
Chemical Engineering

Background:

Dry Powder Inhalers (DPIs) utilize interactive mixtures of low-dose micronized drug particles and larger carrier particles.
Understanding the relationship between bulk powder properties and aerodynamic dispersion is crucial for DPI formulation development.
Current methods for assessing DPI powder performance can be complex and time-consuming.

Purpose of the Study:

To develop a simple method for measuring the air permeability of interactive mixtures used in DPIs.
To correlate air permeability with the aerodynamic dispersion performance of DPI formulations.
To establish a potential tool for screening DPI formulations during early development.

Main Methods:

Utilized Blaine's apparatus, a compendial permeameter, to measure the air permeability of interactive powder mixtures.
Employed fluticasone propionate and terbutaline sulphate as drug models, blended with various lactose carriers of differing particle size distributions.
Assessed blend quality via drug content uniformity and aerodynamic performance using a Twin Stage Impinger.

Main Results:

A linear correlation was observed between the air permeability of the packed powder bed and the fine particle fraction of the drug for the tested models.
Air permeability was found to reflect the quantity of free particles within the powder bed, influencing fine particle fraction during fluidization.
A theoretical approach was developed to link powder bed air permeability with the drag force experienced during aerosolization.

Conclusions:

Air permeability is a valuable bulk property for predicting the aerodynamic performance of DPI interactive mixtures.
The developed permeability technique provides a simple and effective tool for screening and optimizing DPI formulations.
This method has the potential to streamline the development process for Dry Powder Inhalers.