Related Experiment Video
Updated: Jun 8, 2026
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Stool DNA testing to screen for colorectal cancer in the Medicare population: a cost-effectiveness analysis
Iris Lansdorp-Vogelaar1, Karen M Kuntz, Amy B Knudsen
1Erasmus Medical Center, Rotterdam, the Netherlands. i.vogelaar@erasmusmc.nl
Background:
The Centers for Medicare & Medicaid Services considered whether to reimburse stool DNA testing for colorectal cancer screening among Medicare enrollees.
Objective:
To evaluate the conditions under which stool DNA testing could be cost-effective compared with the colorectal cancer screening tests currently reimbursed by the Centers for Medicare & Medicaid Services.
Design:
Comparative microsimulation modeling study using 2 independently developed models.
Data Sources:
Derived from literature.
Target Population:
A cohort of persons aged 65 years. A sensitivity analysis was also conducted, in which a cohort of persons aged 50 years was studied.
Time Horizon:
Lifetime.
Perspective:
Third-party payer.
Intervention:
Stool DNA test every 3 or 5 years in comparison with currently recommended colorectal cancer screening strategies.
Outcome Measures:
Life expectancy, lifetime costs, incremental cost-effectiveness ratios, and threshold costs.
Results Of Base-Case Analysis:
Assuming a cost of $350 per test, strategies of stool DNA testing every 3 or 5 years yielded fewer life-years and higher costs than the currently recommended colorectal cancer screening strategies. Screening with the stool DNA test would be cost-effective at a per-test cost of $40 to $60 for stool DNA testing every 3 years, depending on the simulation model used. There were no levels of sensitivity and specificity for which stool DNA testing would be cost-effective at its current cost of $350 per test. Stool DNA testing every 3 years would be cost-effective at a cost of $350 per test if the relative adherence to stool DNA testing were at least 50% better than that with other screening tests.
Results Of Sensitivity Analysis:
None of the results changed substantially when a cohort of persons aged 50 years was considered.
Limitation:
No pathways other than the traditional adenoma-carcinoma sequence were modeled.
Conclusion:
Stool DNA testing could be a cost-effective alternative for colorectal cancer screening if the cost of the test substantially decreased or if its availability would entice a large fraction of otherwise unscreened persons to receive screening.
