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Related Concept Videos

Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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Related Experiment Video

Updated: Jun 8, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
08:01

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

Published on: February 27, 2026

Interpreting coagulation assays.

David Green1

  • 1Division of Hematology/Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. d-green@northwestern.edu

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|September 22, 2010
PubMed
Summary
This summary is machine-generated.

Understanding coagulation assays like activated partial thromboplastin time and prothrombin time is crucial for diagnosing bleeding disorders and monitoring anticoagulants. These tests, along with D-dimer and mixing studies, aid in complex clinical situations.

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Published on: February 14, 2017

Area of Science:

  • Hematology
  • Clinical Pathology

Background:

  • Coagulation assays are essential for diagnosing and managing hemostatic and thrombotic disorders.
  • Interpreting these assays requires understanding the intrinsic and extrinsic clotting pathways.

Purpose of the Study:

  • To elucidate the principles behind key coagulation assays.
  • To highlight the diagnostic utility of these tests in various clinical scenarios.
  • To emphasize the importance of assay interpretation in patient management.

Main Methods:

  • Review of activated partial thromboplastin time (aPTT) and prothrombin time (PT) assay principles.
  • Discussion of D-dimer measurement and mixing tests.
  • Explanation of the modified Bethesda assay for inhibitor detection.

Main Results:

  • aPTT and PT reflect different sets of clotting factors, aiding in differential diagnosis.
  • These assays are vital for monitoring heparin and warfarin therapy.
  • D-dimer and mixing studies assist in diagnosing thrombosis and differentiating factor deficiencies from inhibitors.

Conclusions:

  • Coagulation assay interpretation is complex and requires specialized knowledge.
  • These assays are indispensable tools in hematology and clinical pathology.
  • Expert consultation may be necessary for challenging cases.