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Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction

Coronoid-Temporalis Pedicled Flap for Orbital Floor Defect Reconstruction

Published on: December 5, 2025

Bilateral orbitozygomatic reconstruction with tissue-engineered bone.

Jesse A Taylor¹

¹Department of Surgery, Division of Plastic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. Jesse.taylor@cchmc.org

The Journal of Craniofacial Surgery

|September 22, 2010

Summary

This summary is machine-generated.

Engineered bone using allograft, stem cells, and growth factors successfully reconstructed critical craniofacial defects. This innovative approach shows promise for bone tissue engineering with reduced patient morbidity.

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Area of Science:

Regenerative Medicine
Biomaterials Science
Craniofacial Surgery

Background:

Traditional treatments for critical bone defects, such as bone grafts and free flaps, often result in significant donor site morbidity and suboptimal outcomes.
The ideal solution involves creating a bone graft that integrates seamlessly, heals, grows, resists infection, and minimizes donor site complications.

Observation:

A 14-year-old boy with Treacher Collins syndrome underwent reconstruction of bilateral orbitozygomatic defects using engineered bone.
The engineered bone composite included human bone allograft, adipose-derived mesenchymal stem cells, bone morphogenic protein-2, and periosteal grafts in a single-stage procedure.

Findings:

Postoperative swelling resolved within 3 weeks, with only minor, transient lid malposition.
A 6-month follow-up revealed stable reconstruction, and a biopsy confirmed the presence of healthy, lamellar bone, indicating successful graft revitalization.
This marks the first demonstration of large-volume allograft bone revitalization in humans.

Implications:

This engineered bone composite offers a promising alternative to conventional free flaps and large structural allografts for craniofacial reconstruction.
The technique potentially reduces surgical morbidity and may lead to improved long-term functional and aesthetic results.
These findings have significant positive implications for the advancement of craniofacial bone tissue engineering.