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Related Experiment Video

Updated: Jun 8, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

Regulatory B cells in autoimmunity: developments and controversies.

Claudia Mauri¹, Paul A Blair

¹Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK. c.mauri@ucl.ac.uk

Nature Reviews. Rheumatology

|September 22, 2010

Summary

Regulatory B (BREG) cells, crucial for immune suppression, have been extensively studied for their role in autoimmunity and disease. Recent advances illuminate their mechanisms, targets, and function in rheumatic diseases.

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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

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Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Published on: January 3, 2025

Area of Science:

Immunology
Cell Biology

Background:

The concept of regulatory B (BREG) cells, capable of immune suppression, has evolved since the 1960s.
Recent research has elucidated key aspects of BREG cell biology, including their mechanisms, targets, and development.

Purpose of the Study:

To review recent advances in regulatory B cell research.
To highlight the phenotype and suppressive functions of BREG cells in autoimmunity, with a focus on rheumatic diseases.

Main Methods:

Literature review of studies on regulatory B cells in mice and humans.
Analysis of BREG cell phenotype and function in various immune-mediated processes.

Main Results:

BREG cells play critical roles in regulating autoimmunity, infectious disease, and cancer responses.
Their suppressive mechanisms and cellular targets are increasingly understood.
BREG cell function is particularly relevant in the context of rheumatic diseases.

Conclusions:

Regulatory B cells are vital immune-modulating cells with significant implications for autoimmune and rheumatic diseases.
Continued research into BREG cell biology offers therapeutic potential for immune-mediated conditions.