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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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Published on: April 11, 2014

Pediatric reference intervals for lymphocyte vitamin C (ascorbic acid).

Alex Levin1, Charmaine DeSouza, Christian Zaarour

  • 1Pediatric Ophthalmology and Ocular Genetics, Wills Eye Institute, Philadelphia, PA, USA.

Clinical Biochemistry
|September 23, 2010
PubMed
Summary
This summary is machine-generated.

New reference ranges for lymphocyte vitamin C (ascorbic acid) in children aged 0-7 years have been established. These findings provide a reliable benchmark for assessing vitamin C levels in pediatric health.

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Area of Science:

  • Pediatric Nutrition
  • Clinical Biochemistry
  • Immunology

Background:

  • Vitamin C (ascorbic acid) is essential for numerous physiological functions.
  • Establishing accurate reference intervals for vitamin C in pediatric populations is crucial for clinical assessment.
  • Previous data on lymphocyte vitamin C levels in young children is limited.

Purpose of the Study:

  • To determine pediatric reference intervals for lymphocyte vitamin C.
  • To provide a reliable benchmark for assessing vitamin C status in children aged 0-7 years.

Main Methods:

  • Prospective study involving 194 healthy children aged 0-7 years.
  • Lymphocytes isolated from blood samples collected during elective surgery.
  • Ascorbic acid levels analyzed using High-Performance Liquid Chromatography (HPLC).
  • Reference intervals established following CLSI and IFCC guidelines.

Main Results:

  • Pediatric reference intervals for lymphocyte vitamin C were determined to be 12.9-52.8 μg/10(8) cells.
  • These reference intervals were found to be independent of age and gender.
  • The established ranges are for healthy, fasted children.

Conclusions:

  • Defined pediatric reference ranges for lymphocyte vitamin C in healthy children (0-7 years).
  • The new reference interval facilitates more reliable assessment of vitamin C status.
  • This can aid in exploring the clinical implications of vitamin C variations on bleeding and other signs.