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Possible application of polyamine graft copolymer to targeting drug delivery
N Muramatsu1, Y Yoshida, T Kondo
1Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Chemical & Pharmaceutical Bulletin
|November 1, 1990
Abstract:
Polystyrene microspheres were coated with polyamine graft copolymer and mixed with rat lymphocyte suspension. In the mixture of T and B cells, the microspheres formed large aggregates, while they were fairly well dispersed in the T cell suspension. This result was understood to be the result of preferential adsorption of B cells to the microspheres, indicating it would be possible to deliver drugs to B cells alone with these copolymer-coated microspheres.