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Relation between serum monocyte chemoattractant protein-1 and coronary collateral development
Asife Sahinarslan1, Sinan A Kocaman, Salih Topal
1Department of Cardiology, School of Medicine, Gazi University, Ankara, Turkey. asifesah@yahoo.com
Insights
Higher levels of monocyte chemoattractant protein-1 (MCP-1) are linked to better coronary collateral development in patients with stable coronary artery disease. This finding suggests MCP-1 may play a key role in the body's natural response to blocked arteries.
Area of Science:
- Cardiology
- Vascular Biology
- Biochemistry
Background:
- Coronary collateral development varies among patients with similar coronary stenosis.
- Monocyte chemoattractant protein-1 (MCP-1) has shown potential in animal studies for influencing collateral vessel growth.
- Investigating serum MCP-1 levels in patients with stable coronary artery disease can elucidate its role in collateralization.
Purpose of the Study:
- To determine if elevated serum MCP-1 levels correlate with enhanced coronary collateral vessel development in patients with stable coronary artery disease.
- To explore the relationship between MCP-1, vascular endothelial growth factor (VEGF), and the extent of coronary collateralization.
Main Methods:
- Eighty-three patients with stable angina and significant coronary stenosis (≥70%) were prospectively enrolled.
- Serum levels of MCP-1 and VEGF were measured.
- Coronary collateral development was assessed using the Rentrop method, categorizing patients into good (grade 2-3) and poor (grade 0-1) collateral groups.
Main Results:
- Patients with good collateral development exhibited significantly higher serum MCP-1 levels compared to those with poor collateralization (288 ± 277 pg/ml vs. 132 ± 64 pg/ml; P<0.001).
- A positive correlation was observed between serum MCP-1 levels and the Rentrop score (r=0.39, P<0.001).
- Good collateral group also showed higher VEGF levels and a greater number of stenotic coronary arteries. Multivariate analysis identified serum MCP-1 as an independent predictor of good coronary collateral development.
Conclusions:
- Elevated serum MCP-1 levels are significantly associated with better coronary collateral development in patients with stable coronary artery disease.
- MCP-1 may serve as a crucial biomarker for assessing the potential for collateral vessel formation in response to coronary artery disease.
Background:
The degree of coronary collateral development is not same in every patient with similar degree of coronary stenosis. In animal studies monocyte chemoattractant protein-1 (MCP-1) has been found to be related to collateral vessel development. In this study we investigated whether a higher serum MCP-1 level is related to better coronary collateral vessel development in patients with stable coronary artery disease.
Method:
Eighty-three patients with stable angina pectoris, who have at least one coronary stenosis equal to or greater than 70% at coronary angiography, were prospectively enrolled. Serum MCP-1 and vascular endothelial growth factor (VEGF) levels were studied. Coronary collateral development was graded according to the Rentrop method. Patients with grade 2-3 collateral developments were included in good collateral group and formed group I. The patients with grade 0-1 collateral developments were included in poor collateral group and formed group II.
Results:
The serum MCP-1 level was significantly higher in good collateral group (288 ± 277 pg/ml vs. 132 ± 64 pg/ml; P<0.001). There was also a positive correlation between serum MCP-1 level and Rentrop score (r=0.39, P<0.001). The patients in the good collateral group also had a significantly higher number of coronary arteries with significant stenosis (1.7 ± 0.7 vs. 1.4 ± 0.6, P=0.049), and higher VEGF levels (322 ± 147 pg/ml vs. 225 ± 161 pg/ml, P=0.007). In multivariate analysis, only serum MCP-1 level (P=0.014, odds ratio: 1.01, 95% confidence interval: 1.002-1.019) was independently related to good coronary collateral development.
Conclusion:
Higher serum MCP-1 level is related to better coronary collateral development.
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