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Localization of Plasma Membrane and Intracellular Neuronal Nicotinic Acetylcholine Receptors Using Quantitative Imaging in Mammalian Cells
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Localization of Plasma Membrane and Intracellular Neuronal Nicotinic Acetylcholine Receptors Using Quantitative Imaging in Mammalian Cells

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Application of alpha7 nicotinic acetylcholine receptor agonists in inflammatory diseases: an overview

Mario B Marrero1, Merouane Bencherif, Patrick M Lippiello

  • 1Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA. mmarrero@mcg.edu

Pharmaceutical Research
|September 23, 2010
PubMed

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Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
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Direct-Acting Cholinergic Agonists: Therapeutic Uses

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Cholinergic Antagonists: Therapeutic Uses

Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:    
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...
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Cholinergic Receptors: Nicotinic

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