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Astrocytic neoplasms of the central nervous system and orbit: a morphologic perspective

Tarik Tihan1, Michele M Bloomer

  • 1Department of Pathology, University of California, San Francisco, UCSF School of Medicine, California, 94143-0102, USA. tarik.tihan@ucsf.edu

Seminars in Diagnostic Pathology
|September 24, 2010
PubMed

Insights

Astrocytic neoplasms are diverse brain and orbital tumors, ranging from benign to malignant. Pathologists distinguish between circumscribed and infiltrating types, crucial for guiding patient management and treatment strategies.

Area of Science:

  • Neuro-oncology
  • Central Nervous System Pathology
  • Ophthalmology

Background:

  • Astrocytic neoplasms represent a broad spectrum of tumors in the central nervous system and orbit.
  • These neoplasms vary significantly in clinical behavior, from surgically curable to untreatable malignant forms.
  • Recent advancements have classified these tumors into circumscribed (solid) and infiltrating (diffuse) categories.

Purpose of the Study:

  • To review the key pathological features of astrocytic neoplasms.
  • To emphasize the importance of morphological recognition in classifying these diverse tumors.
  • To highlight the distinction between circumscribed and infiltrating astrocytic neoplasms for clinical management.

Main Methods:

  • Literature review of astrocytic neoplasms.
  • Analysis of pathological classifications.
  • Discussion of morphological characteristics.

Main Results:

  • Astrocytic neoplasms are pathologically divided into circumscribed and infiltrating types.
  • These categories exhibit distinct biological and clinical features.
  • Accurate morphological recognition by pathologists is paramount for effective management.

Conclusions:

  • The distinction between circumscribed and infiltrating astrocytic neoplasms is critical for patient care.
  • Pathological assessment remains the cornerstone for managing these diverse tumors.
  • Understanding the morphological features aids in predicting tumor behavior and guiding treatment.

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