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Published on: September 9, 2015
Vancomycin MIC for methicillin-resistant coagulase-negative Staphylococcus isolates: evaluation of the broth
Rodrigo M Paiva1, Alice B Mombach Pinheiro Machado, Alexandre P Zavascki
1Unidade de Microbiologia e Biologia Molecular, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 2350 Ramiro Barcelos Street, Porto Alegre 90035-903, RS, Brazil. rpaiva@hcpa.ufrgs.br
Abstract:
Vancomycin MIC results were determined by the broth microdilution (BMD) method and by Etest using 130 methicillin-resistant coagulase-negative staphylococcus bloodstream isolates obtained from a tertiary hospital. The majority (98.5%) of MIC results determined by BMD were ≤1 μg/ml, in contrast to MIC results determined by Etest (72.3% were ≥1.5 μg/ml). The MICs obtained by Etest were, in general, 1- to 2-fold higher than the MICs obtained by BMD.
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