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Graves' disease associated with cerebrovascular disease and antiphospholipid antibody syndrome

Ines Khochtali1, Nadia Hamza, Elyes Gassab

  • 1Endocrinology Unit, Department of Internal Medicine,, Monastir Hospital, Monastir 5000, Tunisia.

International Journal of Endocrinology
|September 24, 2010
PubMed

Insights

This case study highlights a patient with Graves' disease who experienced strokes due to antiphospholipid antibody syndrome. It underscores the link between hyperthyroidism, coagulopathy, and thrombotic events.

Area of Science:

  • Endocrinology
  • Hematology
  • Neurology

Background:

  • Thyroid disorders, particularly hyperthyroidism, are linked to coagulopathy.
  • Hyperthyroidism increases the risk of thromboembolic events.
  • Antiphospholipid antibody syndrome can exacerbate thrombotic risks.

Observation:

  • A patient with Graves' disease presented with stroke.
  • The patient was diagnosed with antiphospholipid antibody syndrome.
  • This indicates a potential link between Graves' disease and this syndrome.

Findings:

  • Graves' disease, a form of hyperthyroidism, was associated with stroke.
  • The co-occurrence of antiphospholipid antibody syndrome was noted.
  • This case illustrates a complex interplay between thyroid dysfunction and autoimmune-mediated thrombosis.

Implications:

  • Highlights the importance of screening for antiphospholipid antibody syndrome in hyperthyroid patients with neurological symptoms.
  • Suggests a need for further research into the mechanisms connecting thyroid disorders and thrombophilia.
  • Informs clinical practice regarding the management of hyperthyroidism in patients with thrombotic risks.

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