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Cellular Adaptation III: Hyperplasia01:26

Cellular Adaptation III: Hyperplasia

Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...
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DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
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Oral focal epithelial hyperplasia.

Pía López-Jornet1, Fabio Camacho-Alonso, Lucero Berdugo

  • 1Department of Oral Medicine, Faculty of Medicine and Dentistry, University of Murcia, Spain. majornet@um.es

The New York State Dental Journal
|September 25, 2010
PubMed
Summary

Focal epithelial hyperplasia (FEH) is a benign oral condition caused by human papillomavirus. This case report details a 31-year-old male diagnosed with FEH, highlighting its common clinical presentation.

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Area of Science:

  • Oral Pathology
  • Dermatology
  • Virology

Background:

  • Focal epithelial hyperplasia (FEH) is a benign, asymptomatic oral mucosal condition.
  • It is characterized by papules, primarily on the lower lip, but also affecting other oral areas.
  • FEH is etiologically linked to specific human papillomavirus (HPV) subtypes, notably HPV 13 and 32.

Observation:

  • A clinical case of a 31-year-old male presenting with oral lesions is described.
  • The lesions exhibited clinical features consistent with Focal epithelial hyperplasia.
  • Histological examination confirmed the diagnosis of FEH.

Findings:

  • The patient's lesions were clinically and histologically identified as Focal epithelial hyperplasia.
  • The presentation aligns with the known epidemiological distribution of FEH across various populations.
  • The case underscores the typical manifestation of FEH, even in adult patients.

Implications:

  • This case contributes to the understanding of Focal epithelial hyperplasia presentation and diagnosis.
  • It reinforces the etiological role of human papillomavirus in FEH.
  • The report serves as a reference for clinicians encountering similar oral lesions.