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Updated: Jun 8, 2026
Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
Published on: January 17, 2020
Remarkable levels of enantioswitching in catalytic asymmetric hydroboration
1Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA.
Abstract:
TADDOL-derived phosphites and phosphoramidites are effective ligands for rhodium-catalyzed asymmetric hydroborations of β,γ-unsaturated amides, achieving up to 99% ee. However, the sense of stereoinduction, R or S, is surprisingly dependent on rather subtle features of the ligand. For example, catalysts employing a TADDOL phenylphosphite and those using the closely related N-methylaniline-derived phosphoramidite of the same configuration give opposite enantiomers of the product. Those derived from optical antipodes give the same product with virtually the same enantioselectivity as illustrated above. The different stereochemical outcomes may reflect fundamental differences in catalyst structure, reactivity, or reaction mechanism.
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