[Clinical significance of detection of IL-2R for non-small cell lung cancer.]
1Department of Thoracic Surgery , The Affiliated Hospital of Shandong Medical University , Jinan 250012 , P. R. China.
Background:
To explore the clinical significance of SIL-2R of serum and IL-2R expression of cancer tissue in non-small cell lung cancer.
Methods:
SIL-2R levels in the serum and IL-2R expression in cancer tissues were detected in 42 non-small cell lung cancer by ELISA and immunohistochemistry respectively.
Results:
Serum SIL-2R level was significantly higher in lung cancer group than that in normal control group ( P < 0. 05) , and significantly higher in stage III, IV disease than that in stage I, II disease ( P < 0. 05) , but it was not associated with histological classification of the cancer ( P > 0. 05) . IL-2R expression was significantly higher in lung cancer tissue than that in normal lung tissue ( P < 0. 05) and was significantly higher in stage III, IV cancer than that in stage I, II cancer ( P < 0. 05) . But it was not related to cancer types ( P > 0. 05) .
Conclusions:
The results suggest that detection of serum SIL-2R and IL-2R expression of the cancer tissue might be useful to predict stages of cancer and monitor the prognosis of patients with lung cancer.