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Aurora kinase inhibitors as anticancer molecules

Hiroshi Katayama1, Subrata Sen

  • 1Department of Molecular Pathology, Unit 951, The University of Texas M.D. Anderson Cancer Center, 7435 Fannin, Houston, TX 77054, USA.

Biochimica Et Biophysica Acta
|September 25, 2010
PubMed

Insights

Aurora kinases A and B are key regulators of cell division, often overexpressed in cancers. Inhibitors targeting these kinases show promise as anticancer therapies by correcting chromosomal instability and related pathways.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Aurora kinases (A, B, and C) are serine/threonine kinases crucial for mitosis.
  • Aurora-A and Aurora-B are highly expressed in somatic cells and implicated in cancer development, including chromosomal instability.
  • Aberrant Aurora kinase expression disrupts tumor suppressor and oncoprotein pathways.

Purpose of the Study:

  • To discuss the functional roles of Aurora kinase-A and -B in cancer-related cellular phenotypes.
  • To review findings on Aurora kinase inhibitors and their mechanisms.
  • To explore future directions for next-generation Aurora kinase inhibitors in cancer therapy.

Main Methods:

  • Literature review of Aurora kinase function in mitosis and cancer.
  • Analysis of preclinical and clinical trial data for Aurora kinase inhibitors.
  • Discussion of molecular mechanisms of Aurora kinase regulation and inhibition.

Main Results:

  • Aurora kinases A and B are vital for mitotic regulation and their dysregulation contributes to oncogenesis.
  • Multiple Aurora kinase inhibitors have demonstrated encouraging results in preclinical studies and early-phase clinical trials.
  • Inhibitors modulate Aurora kinase interactions, impacting cancer-associated pathways.

Conclusions:

  • Aurora kinase inhibitors represent a promising targeted therapy for various cancers.
  • Further development of next-generation inhibitors is warranted to enhance clinical utility.
  • Targeting Aurora kinases offers a strategic approach to combatting cancer-related chromosomal instability and pathway derangements.

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