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Updated: Jun 8, 2026
08:13
Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
Published on: September 26, 2025
A comprehensive molecular interaction map of the budding yeast cell cycle
Kazunari Kaizu1, Samik Ghosh, Yukiko Matsuoka
1Department of Science and Technology, Keio University, Kanagawa, Japan.
Molecular Systems Biology
|September 25, 2010
Summary
Researchers mapped the budding yeast cell-cycle, integrating data from ~600 papers into a comprehensive molecular network. This network reveals key motifs driving cell-cycle robustness and aids systems-level analysis of cellular dynamics.
Area of Science:
- Molecular Biology
- Systems Biology
- Cell Biology
Background:
- Cell-cycle dynamics involve complex molecular machinery crucial for cellular function and disease.
- Integrating disparate knowledge sources into a unified molecular network is essential for systems-level analysis.
Purpose of the Study:
- To create a comprehensive molecular network map of the budding yeast cell-cycle.
- To develop a framework for analyzing cell-cycle network architecture and control mechanisms.
Main Methods:
- Curated cell-cycle reactions from approximately 600 original research papers.
- Abstracted molecular components into signaling, cell-cycle core, and structural planes.
- Performed topological and comparative motif analyses.
Main Results:
- Developed a comprehensive cell-cycle map for budding yeast.
- Identified 194 regulatory motifs, including feed-forward, mutual inhibition, and feedback loops.
- Demonstrated how planar abstraction aids in identifying network functions and control.
Conclusions:
- The open-access cell-cycle map provides a framework for systems-level understanding of cell-cycle dynamics.
- Comparative motif analysis reveals mechanisms contributing to cell-cycle robustness.
- This resource facilitates community-driven research into cell-cycle regulation.
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