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Updated: Jun 8, 2026

Single Molecule Methods for Monitoring Changes in Bilayer Elastic Properties
Published on: November 3, 2008
Ion-channel-like behavior in lipid bilayer membranes at the melting transition
Jill Gallaher1, Katarzyna Wodzińska, Thomas Heimburg
1Department of Physics, East Carolina University, Greenville, North Carolina 27858, USA.
Abstract:
It is well known that at the gel-liquid phase-transition temperature a lipid bilayer membrane exhibits an increased ion permeability. We analyze the quantized currents in which the increased permeability presents itself. The open time histogram shows a "-3/2" power law which implies an open-closed transition rate that decreases like k(t)∝t(-1) as time evolves. We propose a "pore freezing" model to explain the observations. We discuss how this model also leads to the 1/fα noise that is commonly observed in currents across biological and artificial membranes.
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