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Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
Published on: May 9, 2021
Phase synchronization in noise-driven bursting neurons.
Xiufeng Lang1, Qishao Lu, Jürgen Kurths
1Beihang University, Beijing, China. lxf125@yahoo.cn
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|September 28, 2010
Summary
Random intracellular calcium fluctuations can induce bursting in spiking neurons. Common noise also enables synchronous bursting in uncoupled neurons, with synchronization increasing with noise intensity.
Area of Science:
- Computational neuroscience
- Nonlinear dynamics
- Neuronal plasticity
Background:
- Intrinsically spiking neurons exhibit periodic firing patterns.
- Intracellular calcium fluctuations play a crucial role in neuronal function.
- Noise can significantly alter neuronal dynamics and firing patterns.
Purpose of the Study:
- To investigate the generation and synchronization of bursting in spiking neurons under random intracellular calcium fluctuations.
- To elucidate the dynamical mechanism of noise-induced bursting.
- To explore noise-induced synchronization in uncoupled, nonidentical spiking neurons.
Main Methods:
- Stimulation of intrinsically spiking neurons with random intracellular calcium fluctuations.
- Global bifurcation analysis to understand the dynamics of noise-induced bursting.
- Analysis of firing patterns and synchronization in single and coupled neurons.
Main Results:
- Sufficiently strong noise can induce a qualitative change from periodic spiking to bursting modes in single neurons.
- A global bifurcation analysis reveals the dynamical mechanism of noise-induced bursting.
- A pair of uncoupled, nonidentical spiking neurons subjected to common noise can exhibit synchronous bursting.
- Synchronization is enhanced with increasing noise intensity, showing transitions at intermediate levels.
Conclusions:
- Random intracellular calcium fluctuations can act as a noise source to induce bursting in spiking neurons.
- Noise-induced bursting provides a mechanism for generating complex firing patterns.
- Common noise can synchronize the bursting activity of uncoupled, nonidentical neurons, suggesting a potential mechanism for neural coordination.
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