Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Formation of Intermediate Filaments00:57

Formation of Intermediate Filaments

Intermediate filaments are cytoskeletal proteins with higher tensile strength and flexibility than microfilaments and microtubules. Unlike the other two cytoskeletal proteins, intermediate filament formation lacks the enzymatic activity to hydrolyze nucleotides like ATP and GTP to generate energy for polymerization. Therefore, the formation of intermediate filaments is multistep self-assembly. The involvement of any accessory proteins in intermediate filament formation has not yet been reported.
Generation of Straight or Branched Actin Filaments01:14

Generation of Straight or Branched Actin Filaments

The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex. Formin-mediated assembly results in straight filaments, whereas Arp2/3 protein complex-mediated assembly results in branched actin filaments.
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
The Structure of Intermediate Filaments01:19

The Structure of Intermediate Filaments

The intermediate filaments are one of three widely studied cytoskeletal filaments. They are so named as their diameter (10 nm) is in between that of microfilaments (7 nm) and the microtubules (25 nm).  These filaments are highly stable and can remain intact when exposed to high salt concentrations and detergents. These filaments are responsible for providing stability and mechanical support to the cells. They also help in cell adhesion and maintaining tissue integrity.
Intermediate filaments...
Actin Filament Depolymerization01:19

Actin Filament Depolymerization

Actin filaments (F-actin) are composed of actin subunits. The dissociation of actin monomers can occur from either end of F-actin. The rate of dissociation is faster from the minus-end or the pointed end, where the actin subunits exist with a bound ADP, together known as ADP-actin. The depolymerization of F-actin is aided by proteins, including the actin-depolymerizing factor (ADF) and cofilin family of proteins, gelsolin, and glia maturation factor (GMF).
In F-actin, the ADF/cofilin proteins...
Planar Rigid-Body Motion01:22

Planar Rigid-Body Motion

Understanding the movement of a rigid body in planar motion involves recognizing that every particle within this body is traversing a path that maintains a consistent distance from a specific plane. This concept is fundamental in the study of physics and mechanical engineering, and it allows us to comprehend better how objects move in space.
Planar motion is typically divided into three distinct categories. The first is rectilinear translation, demonstrated by a subway train that moves along...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Systematic Review of Modeling Platforms for Atrioventricular Valves in Atrioventricular Septal Defects.

Journal of cardiovascular translational research·2026
Same author

Finite Element Analysis of Upper Airway in Ansa Cervicalis Stimulation for Obstructive Sleep Apnea.

The Laryngoscope·2026
Same author

Capturing Multiscale Dynamics of Aortic Valve Calcification with a Coupled Fluid-Structure and Systems Biology Model.

ACS omega·2026
Same author

ECG-Guided Antiarrhythmic Therapy in Acute Coronary Syndrome: A Multidimensional Assessment of Biomarkers, Cardiac Function, and Quality of Life.

Therapeutics and clinical risk management·2026
Same author

Using interconnected viscoelastic elements to investigate forces and the role of cell properties during cell migration.

Mathematical biosciences·2026
Same author

Flapping counter torque and active control in the escape maneuvers of hummingbirds.

Bioinspiration & biomimetics·2026

Related Experiment Video

Updated: Jun 8, 2026

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles
08:02

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles

Published on: May 5, 2022

Interaction between a flexible filament and a downstream rigid body.

Fang-Bao Tian1, Haoxiang Luo, Luoding Zhu

  • 1Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui 230026, China.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|September 28, 2010
PubMed
Summary

A flexible filament in the wake of a rigid body experiences reduced drag, despite potentially larger vibrations. This hydrodynamic interaction benefits the trailing rigid body, offering insights into aquatic animal movement near structures.

More Related Videos

Drawing and Hydrophobicity-patterning Long Polydimethylsiloxane Silicone Filaments
07:56

Drawing and Hydrophobicity-patterning Long Polydimethylsiloxane Silicone Filaments

Published on: January 7, 2019

Fused Filament Fabrication (FFF) of Metal-Ceramic Components
08:43

Fused Filament Fabrication (FFF) of Metal-Ceramic Components

Published on: January 11, 2019

Related Experiment Videos

Last Updated: Jun 8, 2026

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles
08:02

Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles

Published on: May 5, 2022

Drawing and Hydrophobicity-patterning Long Polydimethylsiloxane Silicone Filaments
07:56

Drawing and Hydrophobicity-patterning Long Polydimethylsiloxane Silicone Filaments

Published on: January 7, 2019

Fused Filament Fabrication (FFF) of Metal-Ceramic Components
08:43

Fused Filament Fabrication (FFF) of Metal-Ceramic Components

Published on: January 11, 2019

Area of Science:

  • Fluid Dynamics
  • Hydrodynamics
  • Biomimetics

Background:

  • Understanding hydrodynamic interactions is crucial for analyzing fluid-structure dynamics.
  • Tandem arrangements of rigid and flexible bodies present complex flow phenomena.
  • Aquatic locomotion and biofouling near structures involve similar wake interactions.

Purpose of the Study:

  • To investigate the hydrodynamic interaction between a flexible filament and a rigid body in tandem.
  • To analyze the motion of the filament and compute drag forces on both bodies.
  • To explore the influence of gap distance and Reynolds number on this interaction.

Main Methods:

  • Numerical simulations were employed to model the fluid-structure interaction.
  • Experimental methods were utilized to validate numerical findings.
  • Drag forces and vibration amplitudes were quantitatively measured.

Main Results:

  • The gap between bodies and Reynolds number significantly influence the interaction dynamics.
  • The flexible filament exhibited increased vibration amplitude but reduced drag.
  • The trailing rigid body experienced notable drag reduction.
  • Filament length, mass ratio, and rigid body shape had minimal impact on qualitative behavior.

Conclusions:

  • The study reveals a unique drag reduction mechanism in rigid-flexible tandem arrangements.
  • Findings contrast with interactions involving two rigid or two flexible bodies.
  • The results provide valuable insights for understanding aquatic animal behavior in complex flow environments.