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Related Experiment Video

Updated: Jun 8, 2026

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

IL-22 induces an acute-phase response.

Spencer C Liang¹, Cheryl Nickerson-Nutter, Debra D Pittman

¹Inflammation and Immunology Research Unit, Pfizer Biotherapeutics Research and Development, Cambridge, MA 02140, USA.

Journal of Immunology (Baltimore, Md. : 1950)

|September 28, 2010

Summary

This summary is machine-generated.

Interleukin-22 (IL-22) influences systemic physiology beyond its local effects on epithelial cells. This cytokine impacts blood counts, coagulation, and induces an acute-phase response, suggesting a broader role in inflammation.

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Area of Science:

Immunology
Physiology

Background:

Interleukin-22 (IL-22) is produced by various immune cells.
IL-22 primarily acts on non-hematopoietic cells like epithelial cells.

Purpose of the Study:

To investigate the systemic effects of IL-22 beyond its direct cellular targets.
To understand IL-22's role in systemic inflammation and acute-phase responses.

Main Methods:

Adenoviral-mediated delivery of IL-22.
Systemic administration of IL-22 protein.
Analysis of systemic biochemical, cellular, and physiological parameters.

Main Results:

IL-22 modulated coagulation factors (fibrinogen) and blood cell counts (platelets, neutrophils, RBCs).
IL-22 induced thymic atrophy, weight loss, and altered renal tubule activity.
Hepatic changes included induced fibrinogen, CXCL1, and serum amyloid A, indicating an acute-phase response.

Conclusions:

Circulating IL-22 induces systemic physiological changes indicative of an acute-phase response.
IL-22 contributes to systemic inflammation beyond its local tissue effects.