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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Digital ischemic loss in systemic sclerosis.

Umaima Marvi1, Lorinda Chung

  • 1Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.

International Journal of Rheumatology
|September 28, 2010
PubMed
Summary
This summary is machine-generated.

Digital ischemic loss in systemic sclerosis (SSc) causes significant morbidity. Early evaluation and medical treatment, including prostacyclin therapy, are crucial to prevent digital loss and amputation.

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Area of Science:

  • Rheumatology
  • Vascular Medicine
  • Dermatology

Background:

  • Digital ischemic loss is a serious complication in systemic sclerosis (SSc).
  • It results from microvascular and macrovascular diseases affecting digital arteries, leading to perfusion defects.
  • This condition significantly impacts patient morbidity.

Purpose of the Study:

  • To summarize current knowledge on risk factors, pathogenesis, evaluation, and treatment of digital ischemic loss in SSc.
  • To emphasize the importance of timely intervention.

Main Methods:

  • Review of existing literature on digital ischemia in SSc.
  • Synthesis of information on pathophysiology, clinical presentation, and management strategies.

Main Results:

  • Digital ischemic loss in SSc stems from intimal proliferation and luminal narrowing in small and large digital arteries.
  • Critical digital ischemia necessitates immediate clinical evaluation and treatment.
  • Intravenous prostacyclin therapy is recommended for hospitalized SSc patients with critical digital ischemia.

Conclusions:

  • Prompt medical management, including prostacyclin therapy, is vital for SSc patients with critical digital ischemia.
  • Surgical interventions are reserved for refractory cases or those with necrotic tissue.
  • Understanding risk factors and pathogenesis aids in effective treatment strategies.