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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Serum selenium concentrations in cirrhotic children.

Nuray Uslu1, Inci Nur Saltik-Temızel, Hülya Demır

  • 1Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, Hacettepe University, School of Medicine, Ankara. nurayu74@yahoo.com

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|September 28, 2010
PubMed
Summary

Children with cirrhosis have lower serum selenium levels than healthy children. This finding suggests that selenium supplementation may be beneficial for pediatric patients with cirrhosis.

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Area of Science:

  • Pediatric Gastroenterology
  • Trace Element Metabolism
  • Clinical Nutrition

Background:

  • Selenium is a vital trace element for human health.
  • Reduced plasma selenium concentrations are observed in adults with cirrhosis.
  • The selenium status in pediatric cirrhosis is not well-established.

Purpose of the Study:

  • To determine serum selenium concentrations in children diagnosed with cirrhosis.
  • To compare serum selenium levels between cirrhotic children and healthy controls.
  • To explore correlations between serum selenium and liver function parameters in pediatric cirrhosis.

Main Methods:

  • Serum selenium concentration was quantified using a spectrofluorometric method.
  • A cohort of 38 cirrhotic children was compared to 41 age- and gender-matched healthy children.
  • Statistical analyses investigated correlations with liver function tests and Child-Pugh classification.

Main Results:

  • Cirrhotic children exhibited significantly lower mean serum selenium concentrations compared to controls (42.4 ± 8.2 μg/L vs. 64.4 ± 16.9 μg/L, p<0.05).
  • No significant differences in serum selenium were found between Child-Pugh class A and B+C cirrhotic children.
  • Serum selenium levels showed no significant correlation with most liver function tests, except for aspartate aminotransferase (Pearson coefficient = -0.34).

Conclusions:

  • Pediatric patients with cirrhosis demonstrate low serum selenium concentrations.
  • The findings support the potential benefit of selenium administration in select cases of pediatric cirrhosis.